Triethylamine → n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide

Participants

Reaction Steps

A solution of 485.2 gm of 3,4-dimethoxyphenylacetyl chloride in 1.1 liters of methylene chloride is added dropwise at 15° to 20° C. to a solution of 246.2 ml of aminoacetaldehyde dimethylacetal and 315 ml of triethylamine in 2.2 liters of methylene chloride, while the mixture is cooled with ice, and then the mixture is stirred for a further hour at 16° to 18° C. It is then extracted several times with water, dried over magnesium sulfate, and concentrated by evaporation. The resulting oil slowly crystallizes out.

Provenance & Evidence