3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one → 3-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Participants

Reaction Steps

A quantity of 59.2 gm (0.2 mol) of 1-(7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl)-3-chloro-propane is hydrogenated in 500 ml of glacial acetic acid in the presence of 5 gm of 10% palladium/charcoal for six hours at 50° C. under a pressure of 5 bar. The catalyst is removed by suction filtration, the glacial acetic acid is distilled off in vacuo, and the residue is neutralized with potassium carbonate, after the addition of water. The precipitate is subjected to suction filtration, washed with water until free from salt, and then dried.

Provenance & Evidence