Acetic Acid → HCID 136332163, compound

HRID 2290263Notes

Reaction equation

HRID 2290263 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[C:12](=[N:14][OH:15])[CH3:13])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[NH2:17][NH:18][C:19]([NH2:21])=[S:20].C(O)(=O)C>CO.O>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[N:17][NH:18][C:19]([NH2:21])=[S:20])[C:12](=[N:14][OH:15])[CH3:13])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 2723789ThiosemicarbazideHCID 73666220HCID 73666220, compound

Product 1

HCID 136332163HCID 136332163, compoundYield 68.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

4'-Acetamido-2-hydroxyiminopropiophenone (1.87 g) was added to a suspension of thiosemicarbazide (1 g) and acetic acid (0.1 ml) in a mixture of methanol (15 ml) and water (3 ml) and then heated at 100° for 39 hours with stirring. After cooling, the resultant precipitates were collected by filtration, washed with methanol, and then dried to give 1.7 g of 4'-acetamido-2-hydroxyiminopropiophenone thiosemicarbazone.

Workup

  1. temperatureheated at 100° for 39 hours
  2. temperatureAfter cooling
  3. customthe resultant precipitates
  4. filtrationwere collected by filtration
  5. washwashed with methanol
  6. customdried

Sources & evidence

ORD record
ord-f5a349fdf78541c49a1a473611b60f36
Source dataset
uspto-grants-1986_10
Patent number
US04616015

Reaction notes

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