Ammonia → HCID 13469412, compound

HRID 2290271Notes

Reaction equation

HRID 2290271 reaction equation
N.C([O:5][CH2:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:17]([CH3:23])[NH:18][C:19](=[O:22])[NH:20][N:21]=2)=[CH:12][CH:11]=1)=[O:8])(=O)C>CO>[OH:5][CH2:6][C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:17]([CH3:23])[NH:18][C:19](=[O:22])[NH:20][N:21]=2)=[CH:14][CH:15]=1)=[O:8]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13469397HCID 13469397, compound

Product 1

HCID 13469412HCID 13469412, compoundYield 51.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated ammonia (1.5 ml) was added to a stirred solution of 6-(4-acetoxyacetylaminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (0.85 g) in methanol (15 ml) and the stirring was continued for 2 hours at room temperature. The resulting precipitates were collected by filtration and recrystallized from 70% aqueous ethanol to give 6-[4-(2-hydroxyacetylamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (0.377 g).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. customrecrystallized from 70% aqueous ethanol

Sources & evidence

ORD record
ord-0cfcdf275ef045bd9ce50afbd4dcd803
Source dataset
uspto-grants-1986_10
Patent number
US04616015

Reaction notes

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