Potassium Iodide → HCID 13469424, compound

Participants

Reaction Steps

Chloroacetyl chloride (1.25 g) was added dropwise to a solution of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.04 g) and triethylamine (1.01 g) in DMF (10 ml) and then stirred for 30 minutes. To the stirred solution were added potassium iodide (0.53 g) and morpholine (4.53 g). The reaction mixture was stirred for 30 minutes and then evaporated in vacuo. To the residue was added water and the resultant solid was collected by filtration, washed with water and recrystallized from aqueous ethanol to give 6-[4-(2-morpholinoacetamido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.13 g).

Provenance & Evidence