Acetic Acid → HCID 13469430, compound

Participants

Reaction Steps

Potassium cyanate (0.516 g) was added to a solution of 6-[4-(3-aminopropylamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (1.66 g), acetic acid (0.382 g) and methanol (10 ml) in water (20 ml), and the mixture was stirred for 60 hours at room temperature. The resulting precipitates were collected by filtration, washed with water and recrystallized from 80% aqueous ethanol to give 6-[4-(3-ureidopropylamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (0.62 g).

Provenance & Evidence