Piperazine → HCID 13688004, compound

Participants

Reaction Steps

The chlorodibenzocycloheptene intermediate thus prepared was dissolved in 50 milliliters of chloroform, the solution added dropwise to a solution of 41.3 grams (480 millimoles) of piperazine in 150 milliliters of chloroform and the resulting mixture stirred for two days. At the end of this time, the mixture was washed successively with 20 percent sodium hydroxide, water, and brine, then dried over potassium carbonate. The drying agent was filtered off and the solvent vaporized to obtain 6.70 grams (100 percent yield) of 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperazine product as residue. A portion of the product was recrystallized from acetonitrile to obtain a purified product, m.p. 139°-141° C. Elemental analyses of the product after drying for 24 hours at 65° C. at 20 millimeters of mercury pressure were as follows:

Provenance & Evidence