Sodium borohydride → HCID 20232248, compound

HRID 2290290Notes

Reaction equation

HRID 2290290 reaction equation
[BH4-].[Na+].[F:3][C:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=2[C:5]=1[F:20]>O.CO>[F:3][C:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[CH:8]([OH:15])[C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=2[C:5]=1[F:20]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 20232274HCID 20232274, compound

Product 1

HCID 20232248HCID 20232248, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent2×

Procedure

In a similar manner, a solution of 0.20 gram (52 millimoles) of sodium borohydride in 5 milliliters of water was added dropwise with stirring to a boiling refluxing solution of 0.50 gram (21 millimoles) of 10,11-difluoro-5H-dibenzo[a,d]cyclohepten-5-one in 50 milliliters of methanol; the stirring and refluxing were continued for one hour, and the mixture thereafter allowed to cool. Most of methanol then was vaporized from the mixture, water added and stirred to obtain white crystalline 10,11-difluoro-5H-dibenzo[a,d]cyclohepten-5-ol intermediate. The latter was washed with water and dried under reduced pressure at about 75° C.

Workup

  1. temperaturethe stirring and refluxing
  2. temperatureto cool
  3. additionadded
  4. stirringstirred

Sources & evidence

ORD record
ord-19602064c3b543b187cb27b67907898e
Source dataset
uspto-grants-1986_10
Patent number
US04616023

Reaction notes

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