Ethyl bromopyruvate → HCID 70466171, compound

HRID 2290319Notes

Reaction equation

[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([CH3:19])[NH:12][C:11]([CH2:20][O:21][CH2:22][C:23]([NH2:25])=[S:24])=[C:10]1[C:26]([O:28][CH2:29][CH3:30])=[O:27].Br[CH2:32][C:33](=O)[C:34]([O:36][CH2:37][CH3:38])=[O:35]>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([CH3:19])[NH:12][C:11]([CH2:20][O:21][CH2:22][C:23]2[S:24][CH:32]=[C:33]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[N:25]=2)=[C:10]1[C:26]([O:28][CH2:29][CH3:30])=[O:27]

Participants

Reactant 2

HCID 66144Ethyl bromopyruvate

HCID 13457229HCID 13457229, compound

Product 1

HCID 70466171HCID 70466171, compound

Procedure

2-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxymethyl}-4-ethoxycarbonylthiazole was prepared by the method of Example 44 but using 2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-thioacetamide and ethyl 3-bromopyruvate as starting materials.

Sources & evidence

ORD record: ord-8a11b320021f495a862ae80f2bfe1d85
Source dataset: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04616024

Reaction notes

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