Sodium borohydride → HCID 15586345, compound

Participants

Reaction Steps

Sodium borohydride (2.72 g) was added portionwise to a stirred solution of 3-[4-(2-hydroxyethyl)-1-piperazinyl]-5-methyl-6-phenyl-1,2,4-triazine (3.6 g) in methanol (15 ml) at room temperature. The reaction mixture was filtered by suction and the filtrate was evaporated. The resultant residue was extracted with ethyl acetate after addition of water, and the extract was washed with brine, dried over sodium sulfate and concentrated to a small volume. The resultant precipitates were collected by filtration, washed with diisopropyl ether and recrystallized from a mixture of ethyl acetate and diisopropyl ether to give 3-[4-(2-hydroxyethyl)-1-piperazinyl]-5-methyl-6-phenyl-2,5-dihydro-1,2,4-triazine (2.28 g), mp 103°~105° C.

Provenance & Evidence