Triethylamine → HCID 20232064, compound

Participants

Reaction Steps

A solution of triethylamine (5.455 g) in chloroform (5 ml) was added dropwise to a stirred solution of 2-amino-1-(2-thienyl)-1-propanone hydrochloride (2.585 g) in chloroform (26 ml) under ice cooling in 5 minutes. To the mixture was added dropwise a solution of ethyl chloroformate (2.929 g) in chloroform (7 ml), and the stirring was continued for 2 hours under the same conditions. The reaction mixture was evaporated, and the residue was dissolved in a mixture of ethyl acetate and water. The organic layer was separated, washed successively with a saturated aqueous solution of sodium bicarbonate, water, 5% hydrochloric acid and water, dried over magnesium sulfate and evaporated to give an oil of 2-(2-ethoxycarbonylaminopropionyl)thiophene (2.752 g).

Provenance & Evidence