化工社化工社 化学情報印刷レポート · 研究参考用
(2-Thienylmethyl)amine → 3-(3,5-Dichloro-2-hydroxyphenyl)-3-{(5-oxo-1-(3-{((2-thienylmethyl)amino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Thienylmethyl)amine | HCID 34005 | — |
| 反応物 | 3-(3-Fluorophenyl)-3-{(5-oxo-1-(3-{(benzylamino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid | HCID 22591754 | — |
| 反応物 | Ethyl 3-amino-3-(3,5-dichloro-2-hydroxyphenyl)propanoate | HCID 22591801 | — |
| 生成物 | 3-(3,5-Dichloro-2-hydroxyphenyl)-3-{(5-oxo-1-(3-{((2-thienylmethyl)amino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid | HCID 10167402 | — |
反応手順
The title compound was analogously synthesized to the preparation of 3-(3-fluorophenyl)-3-{(5-oxo-1-(3-{(benzylamino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid from ethyl 3-amino-3-(3,5-dichloro-2-hydroxyphenyl)propanoate and 2-thienylmethyl amine. MS (ES+): 591 (M+H)+; (ES−): 589 (M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849639B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-2dcac970ba41443aa25c723595a5a9dc |
| 出典メモ | uspto-grants-2005_02 |