Water → HCID 13102709, compound

Participants

Reaction Steps

To 4.33 g of 4-bromophenol dissolved in a 22 ml THF/22 ml DMSO mixture was added 3.1 g of t-BuOK and then 9.39 g of 2,5-bis(n-hexylsulfonyl)pyridine, and the resulting mixture heated at 59° C. for 1 hr. The reaction mixture was cooled to room temperature and then added to approximately 4 to 5 volumes of water. The yellow precipitate which formed was removed by filtration. Recrystallization from CH2Cl2 /ethanol gave the product, 2-(4-bromophenoxy)-5-(n-hexylsulfonyl)pyridine, (52% yield), as white shiny prisms, m.p. 94° C.

Provenance & Evidence