Tetrahydrofuran → HCID 511925, compound

Participants

Reaction Steps

To 4.96 g of p-hydroxybenzophenone in a 25 ml THF/25 ml DMSO mixture was added 3.1 g of t-BuOK and then 9.69 g of 2,5bis((phenylmethyl)sulfonyl)pyridine and the resulting mixture heated at 60° C. for 11/2 hrs. The reaction mixture was allowed to cool overnight, diluted with 4 volumes of water, and the golden-brown precipitate which formed removed by filtration. Recrystallization from CH2Cl2 /ethanol and then from toluene gave the product, phenyl(4-((5-((phenylmethyl)sulfonyl)-2-pyridinyl)oxy)phenyl)methanone, (44% yield), as tan prisms, m.p. 146°-147° C.

Provenance & Evidence