Diazomethane → HCID 13591256, compound

Participants

Reaction Steps

A solutin of diazomethane in ether was added to a solution of 260 mg (0.72 mmol) of tert.-butyl (6R, 7R)-7-benzoylamino-3-hydroxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate in 3 ml of anhydrous methylene chloride at room temperature until a yellow coloration remained. The solvent and excess diazomethane were then evaporated off in vacuo and the residue was chromatographed on 18 g of silica gel (toluene:ethyl acetate 2:3). 169 mg (62%) of the title compound were obtained as a colorless rigid foam.

Provenance & Evidence