Sodium Chloride → HCID 56617608, compound

Participants

Reaction Steps

2.40 g (21.0 mmols) of dry potassium thioacetate were added to a solution, cooled to 0° C., of 3.85 g (20.0 mmols) of tert.-butyl 4-chloroacetoacetate in 40 ml of anhydrous acetonitrile and the mixture was stirred at this temperature for 30 minutes. Thereafter, the mixture was poured into a mixture of NaCl solution and ethyl acetate, the organic phase was separated off and extracted with 2×30 ml of ethyl acetate and the extracts were washed with water and dried over MgSO4. After the solvent had been evaporated off in vacuo and the residue had been chromatographed on 60 g of silica gel (toluene:ethyl acetate 95:5), 3.87 g (83%) of the title compound were obtained as a colorless oil, RF :0.2 (toluene:ethyl acetate 95:5).

Provenance & Evidence