Potassium Carbonate → HCID 13135943, compound

Participants

Reaction Steps

A mixture of 11.7 g. (50 mmole) ethyl 4-(piperazin-1-yl)-benzoate, 13.8 g. (0.1 mole) powdered anhydrous potassium carbonate, 125 ml. acetonitrile and 11.7 g. (50 mmole) 2-bromo-4'-chloroacetophenone (p-chlorophenacyl bromide) is stirred for 20 hours at 20° C. The reaction mixture is then suction filtered and the filter cake is washed with acetone. The combined organic phases are evaporated to dryness in a vacuum to give 15.4 g. (80% of theory) of crude product. After recrystallisation from ethyl acetate, there are obtained 9.8 g. (51% of theory) of pure product; m.p. 152°-153° C. and from the mother liquor a further 1.4 g. (7% of theory) (m.p. 150°-152° C.) of product are obtained.

Provenance & Evidence