反应详情

To a mixture of 27 g. (0.1 mole) n-butyl 4-(piperazin-1-yl)-benzoate hydrochloride and 270 ml. anhydrous pyridine are added at 5°-10° C. 11.4 g. (0.1 mole) methanesulphonyl chloride. The reaction mixture is left to stand overnight at 20° C. and then poured into 250 ml. ice water and extracted twice with methylene chloride. The extracts are dried with anhydrous sodium sulphate and evaporated in a vacuum. After trituration of the residue with ligroin, 17.1 g. (55% of theory) of the desired product are obtained as yellow crystals; m.p. 145°-150° C.

1. additionTo a mixture of 27 g
2. waitThe reaction mixture is left
3. additionpoured into 250 ml
4. extractionice water and extracted twice with methylene chloride
5. dry with materialThe extracts are dried with anhydrous sodium sulphate
6. customevaporated in a vacuum