反应详情

19.6 g. (75 mmole) n-Butyl 4-(piperazin-1-yl)-benzoate are heated to reflux temperature for 12 hours in a mixture of 112 ml. 80% formic acid and 37.5 ml. 40% formaldehyde solution. After cooling, the reaction mixture is poured into 2.5 liters of water, rendered alkaline with 10N aqueous sodium hydroxide solution and extracted with methylene chloride. The methylene chloride extracts are dried and evaporated to give 17.8 g. (86% of theory) of the desired product; m.p. 118°-120° C.

1. temperatureto reflux temperature for 12 hours
2. additionin a mixture of 112 ml
3. temperatureAfter cooling
4. extractionextracted with methylene chloride
5. dry with materialThe methylene chloride extracts are dried
6. customevaporated
7. customto give 17.8 g