Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Propane sultone | HCID 14264 | — |
| Reactant | Ethyl 4-[2-(1-piperazinyl)ethyl]benzoate | HCID 20232457 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 20232642 | HCID 20232642 | — |
Reaction Steps
To a solution of 10.25 g. (39 mmole) ethyl 4-[2-(piperazin-1-yl)-ethyl]-benzoate and 70 ml. anhydrous ethanol, there are added 4.76 g. (39 mmole) 1,3-propanesultone, followed by stirring at 20° C. After standing overnight, the ethanol is stripped off and the residue is treated with diethyl ether and ligroin. After suction filtration, it is recrystallised from ethanol to give 11.2 g. (75% of theory) of the desired compound; m.p. 235°-236° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04616086 |
|---|
| Source dataset | uspto-grants-1986_10 |
|---|
| ORD ID | ord-dc77183d685a48aabbf5b2d0c108994a |
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| Source note | uspto-grants-1986_10 |
|---|
