Potassium Carbonate → HCID 20232465, compound

Participants

Reaction Steps

A mixture of 20.2 g. (50 mmole) of the tosylate of 3,5-di-tert.-butyl-4-hydroxyphenethyl alcohol, 13.8 g. (50 mmole) n-butyl 4-(piperazin-1-yl)-phenylacetate, 6.9 g. (50 mmole) powdered anhydrous potassium carbonate and 200 ml. butan-2-one is maintained at reflux temperature for 24 hours, then suction filtered hot and the filtrate evaporated in a vacuum. The residue is taken up in diethyl ether, the ether phase is extracted twice with water, then dried with anhydrous sodium sulphate and evaporated. By means of ligroin, the product is brought to crystallisation and recrystallised from n-butanol. Yield 14.3 g. (59% of theory); m.p. 103°-105° C.

Provenance & Evidence