Potassium Carbonate → HCID 20232620, compound

Participants

Reaction Steps

A mixture of 13.9 g. (50.2 mmole) p-toluenesulphonic acid (3,5-di-tert.-butyl-4-hydroxyphenethyl)ester, 18.4 g. (45.6 mmole) ethyl 4-[2-(piperazin-1-yl)-ethyl]-phenylacetate, 6.3 g. potassium carbonate and 300 ml. butan-2-one is heated for 8 hours while stirring at reflux temperature. For protection against oxidation, the reaction is carried out under an atmosphere of nitrogen. After cooling, the inorganic precipitate is filtered off with suction, the filtrate is evaporated and the evaporation residue is taken up in diethyl ether. From the ether solution, the hydrochloride is precipitated with hydrogen chloride-containing diethyl ether. After recrystallisation from ethanol, there are obtained 16.4 g. (62% of theory) of the desired compound as hydrochloride; m.p. 247°-250° C.

Provenance & Evidence