HCID 20232567, compound → HCID 20232458, compound

Participants

Reaction Steps

A mixture of 57 g. (0.126 mole) ethyl 3-{4-[2-(1-benzylpiperazin-4-yl)-ethyl]-phenyl}-propionate and 200 ml. ethanol is hydrogenated, with the addition of 10% palladium-charcoal, at 50° C. and 50 bar hydrogen pressure in a shaking autoclave, then allowed to cool and filtered. After evaporation, the residue is dissolved in diethyl ether. The dihydrochloride is now precipitated out by adding hydrogen chloride-containing diethyl ether. The dihydrochloride is triturated with ethanol and filtered off with suction. Yield 31.0 g. (68% of theory) ethyl 3-{4-[2-(piperazin-1-yl)-ethyl]-phenyl}-propionate dihydrochloride; m.p. 243°-244° C.

Provenance & Evidence