反应详情

温度

160 °C

(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone (930 mg), methanol (7.5 ml), and a 28% aqueous ammonia solution (9 ml) were placed in a sealed tube and was stirred at 160° C. overnight. The reaction solution was cooled to room temperature, and the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6,3′-trimethyl-[2,2′]bipyridin-3-ol (109 mg, yield 86%).

1. temperatureThe reaction solution was cooled to room temperature
2. customthe solvent was then removed by distillation under the reduced pressure
3. customthe residue was purified by column chromatography