1H-Pyrazol-3-amine, 5-methyl- → HCID 178442661, compound

HRID 2290508Notes

Reaction equation

HRID 2290508 reaction equation
[CH2:1]([CH:9]([C:14]([CH3:16])=O)[C:10]([O:12]C)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH3:17][C:18]1[NH:22][N:21]=[C:20]([NH2:23])[CH:19]=1>C(O)CCC>[OH:12][C:10]1[N:21]2[N:22]=[C:18]([CH3:17])[CH:19]=[C:20]2[N:23]=[C:14]([CH3:16])[C:9]=1[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 10105178METHYL 2-OCTYLACETOACETATE

Product 1

HCID 178442661HCID 178442661, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

200 g of methyl 2-n-octylacetoacetate and 94 g of 3(5)-amino-5(3)-methylpyrazole in 400 ml of n-butanol are refluxed for 5 hours. The mixture is cooled, and the product is filtered off under suction, washed with cold methanol and dried under reduced pressure at 60° C. to give 191 g of 7-hydroxy-2,5-dimethyl-6-n-octylpyrazolo[1,5-a]pyrimidine of melting point 199° C.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationthe product is filtered off under suction
  3. washwashed with cold methanol
  4. customdried under reduced pressure at 60° C.

Sources & evidence

ORD record
ord-e086054ad03f46feac43026e5f4d25a0
Source dataset
uspto-grants-1986_10
Patent number
US04617303

Reaction notes

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