HCID 20137665, compound → HCID 178432403, compound

HRID 2290511Notes

Reaction equation

HRID 2290511 reaction equation
[CH2:1]([O:6][CH2:7][CH2:8][CH2:9][CH:10]([C:15]([CH3:17])=O)[C:11](OC)=[O:12])[C:2]([CH3:5])([CH3:4])[CH3:3].[NH2:18][C:19]1[N:23]=[CH:22][NH:21][N:20]=1>C(O)(=O)CC>[OH:12][C:11]1[N:20]2[N:21]=[CH:22][N:23]=[C:19]2[N:18]=[C:15]([CH3:17])[C:10]=1[CH2:9][CH2:8][CH2:7][O:6][CH2:1][C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 20137665HCID 20137665, compoundHCID 178418311HCID 178418311, compound

Product 1

HCID 178432403HCID 178432403, compoundYield 57.1%

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

22.0 g (90 millimoles) of methyl 2-[3-(neopentyloxy)propyl]-acetoacetate and 7.14 g (84.9 millimoles) of 3-amino -1,2,4-triazole in 300 ml of boiling propionic acid are allowed to react for 21 hours. The mixture is cooled and then evaporated down, the residue is stirred into ice water, the solution is neutralized with 2N NaOH, and the product is filtered off under suction to give 13.5 g (57%) of colorless crystals of melting point 155°-159° C., which are reacted without further purification.

Workup

  1. customto react for 21 hours
  2. temperatureThe mixture is cooled
  3. customevaporated down
  4. filtrationthe product is filtered off under suction

Sources & evidence

ORD record
ord-cce2f3d222344a3794ead0ce4b164c66
Source dataset
uspto-grants-1986_10
Patent number
US04617303

Reaction notes

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