6,7,8-Trifluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-3-quinolinecarboxylic acid → 7-[3[(Ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-3-quinolinecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 1.0 g (3.06 mmol) of the 6,7,8-trifluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-3-quinolinecarboxylic acid in 10 ml of acetonitrile was added 0.46 g of 1,8-diazobicyclo[5.4.0]undec-7-ene and 0.39 g of 3-[(ethylamino)methyl]pyrrolidine. The reaction was warmed to 60° C. for one hour and was then taken to room temperature and stirred overnight. The solids were filtered and washed with ether to give 0.32 g of 7-[3[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-3-quinolinecarboxylic acid, mp 200°-207° (dec).

Provenance & Evidence