Ethyl-pyrrolidin-3-ylmethyl-amine → HCID 85734273, compound

Participants

Reaction Steps

To 0.88 g (2.75 mmol) of the 6,7,8-trifluoro-1,4-dihydro-4-oxo-1-phenyl-3-quinolinecarboxylic acid in 15 ml of acetonitrile was added 0.418 g (1.05 equivalents) of 1,8-diazobicyclo[5.4.0]undec-7-ene and 0.32 g (1.0 equivalent) of 3-[(ethylamino)methyl]-pyrrolidine. The reaction was refluxed for one hour and was stirred overnight at room temperature. The mixture was filtered to give 0.75 g of 7-[3-(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-1-phenyl-3-quinolinecarboxylic acid, mp 258°-260° C.

Provenance & Evidence