Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Chlorobenzyl alcohol | HCID 70117 | — |
| Reactant | Rolziracetam | HCID 71893 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 15588873 | HCID 15588873 | — |
Reaction Steps
Two hundred and eighty eight milligrams of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione (III) are dissolved in 600 mg of m-chlorobenzyl alcohol and 0.2 ml of concentrated hydrochloric acid is added. The solution is heated at 100° C. for 40 hours. The mixture is cooled and is dissolved in 50 ml of anhydrous diethylether. The filtrate is cooled to induce crystallization and the resulting crystals are isolated by filtration. Recrystallization from toluene-petroleum ether yields 5-oxo-2-pyrrolidinepropanoic acid m-chlorobenzyl ester with a melting point of 90°-91° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04617310 |
|---|
| Source dataset | uspto-grants-1986_10 |
|---|
| ORD ID | ord-cd57e35426eb4f8cb7528d340321a6dd |
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| Source note | uspto-grants-1986_10 |
|---|
