Phosphorus oxychloride → HCID 54286513, compound

Participants

Reaction Steps

A solution of 3.0 mmol of 2-(2-nitro-1-imidazoyl)ethanol in 17 ml dry THF is added dropwise over 1 hr to 7.0 mmol phosphorus oxychloride in 5 ml THF at -7° to -2° C. with stirring. The suspension is stirred for another 75 min at 0° C., then allowed to reach room temperature and filtered. The residual powder is washed under a nitrogen flow with THF and the solvent and excess POCl3 removed from the filtrate in vacuo over 1 hr to yield 2-(2-nitro-1-imidazoyl)ethyl phosphorodichloridate as an oil.

Provenance & Evidence