反应详情

温度

23 °C

To a solution of water (5.6 mL) in sulfuric acid (21 mL) at 20° C. was added the 4,6-dichloro-2,5-dimethylpyrimidine (9.3 g, 52.5 mmol). The reaction mixture was stirred for 2 hours at 23° C. and then poured onto ice to which sodium hydroxide (16 g, 400 mmol) had been added. When the ice melted, sodium chloride (60 g) was dissolved in the solution which was then extracted with ethyl acetate. The combined ethyl acetate extracts were dried, filtered, and concentrated in vacuo to afford 7.8 g (94%) of product as a fluffy white solid. The recrystallization of the product from ethanol provided an analytically pure sample, m.p. 224°-225° C.

1. additionhad been added
2. extractionwas then extracted with ethyl acetate
3. dry with materialThe combined ethyl acetate extracts were dried
4. filtrationfiltered
5. concentrationconcentrated in vacuo