HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Methoxy-4-methyl-8-phthalimido-5-(3-trifluoromethylphenoxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | 4-Methyl-5-(3-trifluoromethylphenoxy)-6-methoxy-8-aminoquinoline | HCID 13004203 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 6-Methoxy-4-methyl-8-phthalimido-5-(3-trifluoromethylphenoxy)quinoline | HCID 13745924 | 100% |
Reaction Steps
A mixture of 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline (I) (6.96 g, 20 mmol) and phthalic anhydride (3.25 g, 22 mmol) in xylene (100 mL) was refluxed with water removal via a Dean-Stark trap for 24 hours. After cooling, filtration gave 9.5 g (100%) of the title compound, mp 228°-30° C. Recrystallization from ethanol raised the mp to 228°-31° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04617394 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-71695aed5bdf41778ed1d0ce5745a144 |
| Source note | uspto-grants-1986_10 |