Ammonium Acetate → HCID 13749916, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.21 g (4.0 mmol) of methyl 2-carbomethoxy-6-chloro-3,4-dimethoxybenzenecarbamate and 3.17 g (20 mmol) of ammonium acetate was prepared and heated to 128° C. A solution was obtained and after one hour a white solid precipitated. The reaction mixture was cooled to room temperature, 25 mL of water was added, and the reaction mixture was cooled to 5° C. The product was filtered and washed with 2×5 mL of distilled water and 1×10 mL of methanol. Drying under vacuum gave 500 mg (49%) of white product, mp 286°-289° C. NMR (TFA) δ 4.02 (s, 3H, OCH3), 4.12 (s, 3H, OCH3), 7.60 (s, 1H, ArH), 9.68 (br s, 1H, NH).

Provenance & Evidence