Sodium Hydroxide → HCID 13745939, compound

Participants

Reaction Steps

The compound from Example 16 (650 mg, 1.63 moles) was taken up in 5 ml THF to which was added 1 N NaOH (4.2 ml). After three hours, the reaction volume wad diluted with H2O and the THF was removed in vacuo. The aqueous phase was wahsed with CHCl3, then acidified and extracted into CHCl3. The organic extract was dried and concentrated. The residue was triturated with ether to afford the title compound as a white solid which was recrystallized from toluene, m.p.: 104°-106°.

Provenance & Evidence