Bromotrimethylsilane → HCID 20229905, compound

HRID 2290681Notes

Reaction equation

HRID 2290681 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=2)=[CH:6][C:5]=1[NH:21][CH2:22][P:23](=[O:30])([O:27]CC)[O:24]CC)([O-:3])=[O:2].C[Si](C)(C)Br>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][N:12]=2)=[CH:6][C:5]=1[NH:21][CH2:22][P:23](=[O:24])([OH:27])[OH:30])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 76113BromotrimethylsilaneHCID 20229893HCID 20229893, compound

Product 1

HCID 20229905HCID 20229905, compound

Conditions

Temperature
20 °C

Procedure

A mixture of 3 g of diethyl N-[2-nitro-5-(5-trifluoromethyl-2-pyridyloxy)phenyl]-aminomethylphosphonate and 5 g of trimethylbromosilane is stirred for 18 hours at 20° C. Excess trimethylbromosilane is removed by evaporation and the residue is then taken up in ethanol and the solution is concentrated, affording 2.51 g (96.9% of theory) of the title compound with a melting point of 94° C. (decompos.).

Workup

  1. customExcess trimethylbromosilane is removed by evaporation
  2. concentrationthe solution is concentrated

Sources & evidence

ORD record
ord-ce1da8bdd06d46d0a5b1f92a27e9b15d
Source dataset
uspto-grants-1986_10
Patent number
US04618358

Reaction notes

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