Thionyl Chloride → 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoyl chloride

Participants

Reaction Steps

2-Nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzoic acid (80 grams) and toluene (80 ml) were charged into a reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. Thionyl chloride (80 ml) was slowly added at room temperature with stirring. After the addition was completed, the mixture was heated at reflux with continued stirring for a period of one hour. Stirring was thereafter continued at room temperature overnight. After this time the reaction mixture was stripped of toluene to yield the desired product as an oil.

Provenance & Evidence