Pyridine → HCID 13386049, compound

Participants

Reaction Steps

A mixture of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (1.5 g), methyl isocyanate (0.48 ml) and pyridine (40 ml) was stirred at room temperature for 4.5 hours, and ethanol (5 ml) was added. The solvent was then distilled off under reduced pressure. To the oily residue was added 10% HCl, and the thus-produced crystals were collected by filtration, washed with water, dried and recrystallized from aqueous dimethylformamide to give 6-[4-(3-methylureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (1.43 g).

Provenance & Evidence