HCID 13386035, compound → HCID 135847670, compound

Participants

Reaction Steps

6-(4-Benzyloxyphenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (1.5 g) obtained by the procedure of Examples 3-(1) to 3-(5) was dissolved in acetic acid (36 ml) and the hydrogenolysis reaction was carried out with 5% palladium on carbon (1.6 g) at atmospheric pressure and room temperature. After the theoretical amount of hydrogen gas had been absorbed, the catalyst was filtered off and the filtrate was concentrated to dryness under reduced pressure. To the residue was added water and the solid which formed was collected and recrystallized from 90% ethanol to give 6-(4-hydroxyphenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (0.42 g).

Provenance & Evidence