Methanethiol → HCID 20230485, compound

Participants

Reaction Steps

A 1-g sample of 2'-hydroxy-5'-[1-chloro-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride is slowly added to 5 mL of methylmercaptan in 25 mL of ethylene dichloride at 0° to -10° C. under N2 atmosphere. This mixture is first stirred several hours at ice-bath temperature and then stirred at ambient temperature for 24 hours. The mixture is filtered. The filter cake is washed with ethylene dichloride, added to water, and basified with 10% NaOH solution to pH 10 in an ice bath. The aqueous mixture is extracted several times with methylene chloride. The combined extracts are dried over MgSO4 and evaporated to dryness thus yielding the crude product compound.

Provenance & Evidence