Flurbiprofen → HCID 54138771, compound

HRID 2290774Notes

Reaction equation

HRID 2290774 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=O)[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[O:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]1[O:25][CH2:26][CH2:27][C:28](=[N:30]O)[NH2:29]>>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:8]([C:9]1[O:11][N:30]=[C:28]([CH2:27][CH2:26][O:25][CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24][O:19]2)[N:29]=1)[CH3:12]

Participants

3

Reactant 2

HCID 3394FlurbiprofenHCID 54037567HCID 54037567, compound

Product 1

HCID 54138771HCID 54138771, compound

Procedure

According to substantially the same procedure as that of Example 1, treatment of 5.38 g of 2-(2-fluoro-4-biphenylyl)propionic acid with 4.56 g of 3-tetrahydropyranyloxypropionamidoxime yielded 5-(3-fluoro-4-phenyl-α-methylbenzyl)-3-(2-tetrahydropyranyloxyethyl)-1,2,4-oxadiazole.

Sources & evidence

ORD record
ord-caecf1e36ebb42ce8d8174eddb9ee558
Source dataset
uspto-grants-1986_10
Patent number
US04618617

Reaction notes

Loading…