Bromine → HCID 13691074, compound

Participants

Reaction Steps

To a solution of 0.5 g of 1-(3,4-dihydroxyphenyl)-4-methyl-3-octanol obtained in Example 1 in 20 ml of acetic acid was added dropwise a mixture of 0.37 g of bromine and 2 ml of acetic acid and after the color of bromine disappeared, the solvent was distilled off under reduced pressure. The residue thus formed was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was applied to silica gel column chromatography and eluted with a mixture of toluene and ethyl acetate (2:1) to provide 0.5 g of 1-(2-bromo-4,5-dihydroxyphenyl)-4-methyl-3-octanol.

Provenance & Evidence