Hydrochloric Acid → HCID 131714757, compound

Participants

Reaction Steps

The above hydrochloride (15 g), 400 ml of methanol, 10 ml of water, 8 ml of concentrated hydrochloric acid, and 1 g of 10% palladium on carbon were shaken with hydrogen (50 psig initial pressure) for 4.5 hours. The catalyst was separated and the filtrate was evaporated to dryness in vacuo. The residue was dissolved in methylene chloride and shaken with saturated sodium carbonate solution. The methylene chloride solution was separated and a precipitate formed after 20 minutes. The mixture was filtered to obtain 6.5 g of solid, m.p. 170°-3° C. The solid was dissolved in methanol and treated with hydrogen chloride to obtain 4.9 g of the title compound as the hydrochloride.

Provenance & Evidence