HCID 20230815, compound → HCID 13770962, compound

HRID 2290846Notes

Reaction equation

HRID 2290846 reaction equation
C([CH:8]([NH:12][C:13]([NH:15][OH:16])=[O:14])[C:9]([O-:11])=[O:10])C1C=CC=CC=1.[H][H]>[Pd].CO>[OH:16][NH:15][C:13](=[O:14])[NH:12][CH2:8][C:9]([OH:11])=[O:10]

Participants

5

Reactant 2

HCID 20230815HCID 20230815, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 13770962HCID 13770962, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5 g of palladium on activated charcoal are added to a solution of 22.4 g (0.1 mole) of benzyl-3-hydroxy-ureido-acetate in 300 ml of methanol. Hydrogen is introduced with shaking. After about 20 minutes the hydrogen uptake is finished. The catalyst is filtered off with suction and the filtrate is evaporated in a vacuum. The solid residue of crude 3-hydroxy-ureido-acetic acid is recrystallized from dioxane.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. customthe filtrate is evaporated in a vacuum
  3. customThe solid residue of crude 3-hydroxy-ureido-acetic acid is recrystallized from dioxane

Sources & evidence

ORD record
ord-50389ce58d3b43328866d4e4eb550809
Source dataset
uspto-grants-1986_10
Patent number
US04618692

Reaction notes

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