Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-Chlorobenzyl-2,5-dimethylpiperazine | HCID 22313576 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine | HCID 20153190 | 58% |
반응 단계
22.0 g g of 1-bromo-3-chloropropane were added to a mixture of 33.0 g of 4-chlorobenzyl-2,5-dimethylpiperazine, 25.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide. After stirring the solution for 3 hours at room temperature, water was added, the product was extracted with ether, and the extract was dried (magnesium sulfate) and concentrated to give 25.8 g (58% of theory) of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine as an oil, suitable for use in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04618677 |
| 출처 데이터셋 | uspto-grants-1986_10 |
| ORD ID | ord-51520f7cad054d9eb13690fbfc0b08c3 |
| 출처 메모 | uspto-grants-1986_10 |