HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine | HCID 20153190 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride | HCID 20153172 | 249.9% |
Reaction Steps
The procedure described in Example 1(b) was followed, using 12.7 g of thiourea and 26.0 g of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine in 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 26.5 g (83% of theory) of 3-[4-(4-chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 168°-171° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04618677 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-bd7a771070a7451fbe1adea501177caa |
| Source note | uspto-grants-1986_10 |