HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-Phenethylpiperazine | HCID 79214 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153179 | 188.8% |
Reaction Steps
The procedure described in Example 1(a) was followed, using 29.4 g of 1-phenethyl piperazine, 25.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 24.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 32.6 g (64% of theory) of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride as an off-white crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04618677 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-aff75458a7f94c429ebebaaf3f8ceb03 |
| Source note | uspto-grants-1986_10 |