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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2290875Generated: October 26, 2026

1-Bromo-3-chloropropane → 1-(4-Chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

https://huagongshe.com/reaction/2290875

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant1-[2-(4-Chlorophenyl)ethyl]piperazineHCID 12235714—
SolventDimethyl SulfoxideHCID 679—
Product1-(4-Chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochlorideHCID 20153182118.3%

Reaction Steps

The procedure described in Example 17(a) was followed, using 6.5 g of 1-(4-chlorophenethyl)piperazine, 6.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 4.6 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 6.4 g (59% of theory) of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04618677
Source datasetuspto-grants-1986_10
ORD IDord-7b80716b45d64e679201511e1525b033
Source noteuspto-grants-1986_10