HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-[4-(3-Phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 1-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153184 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[4-(3-Phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride | HCID 13731128 | 82% |
Reaction Steps
The procedure described in Example 1(b) was followed, using 19.0 g of thiourea, 44.0 g of 1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride, 25 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 35.8 g (82% of theory) of 3-[4-(3-phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 237°-239° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04618677 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-f7ab08950f664f80962854dbf79fa97a |
| Source note | uspto-grants-1986_10 |