HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(4-Fluorobenzyl)piperazine | HCID 796563 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride | HCID 20153168 | 179.2% |
Reaction Steps
The procedure described in Example 1(a) was followed, using 32.8 g of 1-(4-fluorobenzyl)piperazine, 30.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 27.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 35.2 g (61% of theory) of 1-(4-fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride as a white crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04618677 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-7e68371e459f4148b0feaf1d01c2a207 |
| Source note | uspto-grants-1986_10 |