Phenyl isocyanate → HCID 178418532, compound

HRID 2290890Notes

Reaction equation

HRID 2290890 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:10][C:11]1[CH:26]=[CH:25][C:14]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][SH:24])[CH2:18][CH2:17]2)=[CH:13][CH:12]=1>C(Cl)Cl>[ClH:10].[ClH:10].[C:1]1([NH:7][C:8](=[SH:24][CH2:23][CH2:22][N:19]2[CH2:20][CH2:21][N:16]([CH2:15][C:14]3[CH:25]=[CH:26][C:11]([Cl:10])=[CH:12][CH:13]=3)[CH2:17][CH2:18]2)[OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 13731202HCID 13731202, compound

Product 1

HCID 178418532HCID 178418532, compoundYield 128.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure described in Example 35 was followed, using 1.3 g of phenyl isocyanate, 3.0 g of 2-[4-(4-chlorobenzyl)piperazin-1-yl]ethanethiol and 100 ml of methylene chloride, to give 2.2 g (43% of theory) of N-phenyl-S-{2-[4-(4-chlorobenzyl)piperazin-1-yl]ethyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 232°-236° C. (dec.).

Sources & evidence

ORD record
ord-115c8998748941528fe78d00509fffeb
Source dataset
uspto-grants-1986_10
Patent number
US04618677

Reaction notes

Loading…